Dude, getting a S-S-H or a H-S-H would be ideal for the maximum variety of tones.
You also don't want too many options as while playing live, getting the right pick up can be a problem if you have too many options.
Anyway pick up companies now come out with such a range of p/ups that you can convert humbuckers to single coil sound and you get stacked single coils that have output like humbuckers. Also, now they produce pups that are eq'd so differently that you can get usable clean tones from bridge pups too. Most manufacturers now produce noiseless single coils so that they are humbucking and can be used with high gain amps without uncontrollable feedback.
Your best bet is to start from the setup that the artist you most want to sound like has.
-- My current rig
Guitar: '98 MIJ Ibanez RG520 QS w EMG 81/60
Amp: Laney LC15R Tube, Fernandes 20W SS
Pedals: MI Audio Tube Zone Overdrive, Boss OD3, CS3, MT2, HM2, DS2, CE5, DD7, TU3, Beta Aivin DD2 Delay, Dunlop Crybaby 95Q, Stranger Vol Pedal, BBE SupaCharger
Others: Yamaha RBX 374 Bass, Yamaha MM-6 Synth, M-Audio Fast Track, Shure SM-57, Heet Sound E-Bow Plus
Wanted(pm if selling): EB VPJr/Boss FV500L,Ibanez w Original/Lo-Pro Edge